4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-ol, (HCl salt)

4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-ol, (HCl salt)

4,5,6,7-Tetrahydroisoxazolo[5,4-c]Pyridin-3(2H)-One Monohydrochloride

CAS: 85118-33-8

Molecular Formula: C6H9ClN2O2

4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-ol, (HCl salt) - Names and Identifiers

Name	4,5,6,7-Tetrahydroisoxazolo[5,4-c]Pyridin-3(2H)-One Monohydrochloride
Synonyms	Einecs 285-687-7 GABOXADOL HYDROCHLORIDE THIP HYDROCHLORIDE (GABOXADOL) POST-SYNA PTIC GABA RE 4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-ol, (HCl salt) 4,5,6,7-tetrahydro-[1,2]oxazolo[5,4-c]pyridin-6-ium-3-olate 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3(2H)-one monohydrochloride 4,5,6,7-Tetrahydroisoxazolo[5,4-c]Pyridin-3(2H)-One Monohydrochloride Isoxazolo[5,4-c]pyridin-3(2H)-one, 4,5,6,7-tetrahydro-, Monohydrochloride THIP hydrochloride, 4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-ol hydrochloride
CAS	85118-33-8
EINECS	285-687-7

4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-ol, (HCl salt) - Physico-chemical Properties

Molecular Formula	C6H9ClN2O2
Molar Mass	176.60086
Melting Point	236 °C
Solubility	ethanol: soluble0.91mg/mL
Appearance	solid
Color	white
Merck	14,4321
Storage Condition	Keep in dark place,Inert atmosphere,Room temperature
In vitro study	Gaboxadol hydrochloride (0.34, 3.5 and 7.0 μM) decreses permeability across Caco-2 cell monolayers with a dose dependent manner, shows the mean P app values with 8.1 × 10 -6 cm·s -1 , 6.1 × 10 -1 cm·s -6 and 5.6 × 10 -6 cm·s -1 for 0.34, 3.5 and 7 μM gaboxadol, respectively.
In vivo study	Gaboxadol hydrochloride (intraperitoneal injection; 0.5, 1, 1.5, 2, 3, 4, or 5 mg/kg; once daily; three-day interval) normalizes the distance traveled byFmr1KO2 mice to WT activity levels at 0.5mg/kg, additionally, this compound has no effect on locomotor activity inFmr1KO2 mice. Animal Model: Fmr1KO2 mice (deletion of the promoter and first exon ofFmr1resulting in mRNA and protein null mice) Dosage: 0.5, 1, 1.5, 2, 3, 4, or 5 mg/kg Administration: Intraperitoneal injection Result: Normalized Hyperactivity Observed inFmr1KO2 mice.

4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-ol, (HCl salt) - Risk and Safety

Safety Description	S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes.
WGK Germany	3
RTECS	NY3396800

4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-ol, (HCl salt) - Reference Information

biological activity	Gaboxadol hydrochloride (Lu 02-030 hydrochloride; THIP hydrochloride) is a powerful agonist of GABAA receptor and GABAC receptors receptor antagonist (IC50=25 μM). The Gaboxadol hydrochloride shows partial agonist efficacy in the subunit α1β2γ2, with an ED50 value of 143 µM, a complete receptor agonist efficacy in the α5 subunit (ED50=28-129 µM) and in the α4β3δ subunit It also has an agonistic effect (ED50=6 µM). Gaboxadol hydrochloride is a non-opioid analgesic agent and has hypnotic effects.
target	GABA A receptor; GABA C receptor
in vitro study	Gaboxadol hydrochloride (0.34, 3.5 and 7.0 μ m) decreses permeability across Caco-2 cell monolayers with a dose dependent banner, shows the mean P app values with 8.1 × 10 -6cm s -1 , 6.1 × 10 -1cm s -6 and 5.6 × 10 -6cm s -1 for 0.34, 3.5 and 7 μ m gaboxadol, respectively.
in vivo study	Gaboxadol hydrochloride (intraperitoneal injection; 0.5, 1, 1.5, 2, 3, 4, or 5 mg/kg; once daily; Three-day interval) normalizes the distance traveled byFmr1KO2 ice to WT activity levels at 0.5 mg/kg, additionally, this compound has no effect on locomotor activity inFmr1KO2 mice. Animal Model: Fmr1KO2 mice (deletion of the promoter and first exon ofFmr1resulting in mRNA and protein null mice) Dosage: 0.5, 1, 1.5, 2, 3, 4, or 5 mg/kg Administration: Intraperitoneal injection Result: Normalized Hyperactivity Observed inFmr1KO2 mice.
Animal Model:	Fmr1KO2 mice (deletion of the promoter and first exon ofFmr1resulting in mRNA and protein null mice)
Dosage:	0.5, 1, 1.5, 2, 3, 4, or 5 mg/kg
Administration:	Intraperitoneal injection
Result:	Normalized Hyperactivity Observed inFmr1KO2 mice.

Last Update：2024-04-09 20:52:54

4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-ol, (HCl salt)

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CAS: 85118-33-8
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Shanghai Yuanye Bio-Technology Co., Ltd.

Product Name: 4,5,6,7-Tetrahydroisoxazolo[5,4-c]Pyridin-3(2H)-One Monohydrochloride Visit Supplier Webpage Request for quotation
CAS: 85118-33-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Click to send a QQ message

Wechat: 18301782025

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